Question

The ribosome can transfer any peptidyl group from the P-site tRNA to any aminoacyl group on the A-site RNA, but the rate may vary with the identities of those groups. Propose an explanation of why the ribosome synthesizes poly-Pro sequences extremely slowly compared to other peptide sequences.

Short answer

Pro has a constrained geometry, which reduces the amino acid's synthesis.

Step-by-step solution

Definition of Concept

Nucleotide sequence: The primary structure of a molecule of DNA is the sequence of nucleotides that make it up.Two of these chains of polymerized nucleotides run side by side in a DNA molecule, joined by hydrogen bonds formed between their nitrogenous bases.

Acids: Any hydrogen-containing substance that candonate a proton (hydrogen ion) to another substance is referred to as an acid.

Explain the ribosome synthesizes poly-Pro sequences extremely slowly compared to other peptide sequences

The ribosome synthesizes poly-Pro sequences extremely slowly compared to other peptide sequences because the peptidyl transfer and poly-Pro do not fit perfectly into the ribosome exit tunnel configuration, slowing chain lengthening.