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Ways of Studying the Brain

To study the brain in psychology, we need tools that accurately represent the complex organ and provide data scientists and medical personnel can analyse. These data must reflect the brain activity and functions and show precisely where the activity occurs in the brain. Modern technology has made significant advances in studying the brain in relation to behaviour, allowing more profound, less…

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Ways of Studying the Brain

Ways of Studying the Brain

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To study the brain in psychology, we need tools that accurately represent the complex organ and provide data scientists and medical personnel can analyse. These data must reflect the brain activity and functions and show precisely where the activity occurs in the brain.

Modern technology has made significant advances in studying the brain in relation to behaviour, allowing more profound, less invasive insights into how the mind works. However, the history of how the brain was studied before this time is still critical and was essential to the discovery of language centres before these new experimental techniques became available. So we will cover both the older ways of studying the brain in psychology and the modern methods of studying the brain.

  • We are going to delve into the different ways of studying the brain in psychology.
  • First, we will establish the different techniques used to study the brain, particularly in relation to behaviour.
  • We will highlight modern ways of studying the brain, as well as older ways of studying the brain.
  • Finally, we will then briefly provide a way of studying the brain evaluation.

Ways of Studying the Brain, Studying the brain tools and explanation, VaiaFig. 1: There are multiple ways of studying the brain.

Ways of Studying the Brain in Psychology

There are a variety of methods available for studying the brain in psychology. Before delving into these methods, however, here are some important terms to remember:

Spatial resolution is the degree of accuracy that a technique achieves when examining brain activity. It is the accuracy with which the exact areas of brain structures and activity are identified.

Temporal resolution is the degree of accuracy in determining brain activity over time that the technique provides. It relates to when the activity virtually occurred and how accurately the technique can record this information.

The main ways of studying the brain consist of:

  1. Post mortem examinations
  2. Functional Magnetic Resonance Imaging (fMRI)
  3. Electroencephalograms (EEGs) and Event-related Potentials (ERPs)

That's not to say these are the only methods of studying the brain. Other techniques exist, such as computerised tomography scans (CT scans) and positron emission tomography scans (PET scans), however, our focus will be on the aforementioned three methods for this explanation.

Methods of Studying the Brain in Psychology

As we mentioned briefly above, the three main techniques of studying the brain we are going to focus on are post-mortem examinations, functional magnetic resonance imaging (fMRI), electroencephalograms (EEGs) and event-related Potentials (ERPs). Each has its own preferred method of analysing the brain and its components. Let's explore them further.

Post-mortem Examinations of the Brain

Post-mortems were the first official technique for examining the brain. It is now usually performed by pathologists who examine the body and brain after death.In a post-mortem, the brain is treated with a chemical fixative to make it resistant to handling and cutting. This way we can analyse the different sections. Usually, autopsies are good for finding damaged areas of the brain and assigning the injured area to a function, depending on how the patient behaved or suffered while alive.

Broca's area, located in the left hemisphere, is a good example of where a post-mortem examination could identify a functional area in the brain after a patient had suffered from speech problems while alive.

Ways of Studying the Brain, Post mortem examination illustration of hands cutting into the open skull of a person's head, VaiaFig. 2: Post-mortem examinations look at the brain after death.

Functional Magnetic Resonance Imaging (fMRI): Modern Ways of Studying the Brain

Functional Magnetic Resonance Imaging (fMRI) detects the change of blood flow in the brain using a magnetic field and is one of the modern ways of studying the brain. This technique can also be used on the brain in relation to behaviour. It does this by detecting the change and flow of oxygenated and deoxygenated haemoglobin during neural activity.

Active brain areas consume more blood (they need more oxygen and glucose to perform activities) and fMRI machines can measure this (the BOLD signal, Blood-Oxygenation-Level-Dependent). fMRI scans provide 3D images of the brain, producing a neuroimage of the brain with areas of activity highlighted. It is a great diagnostic tool as a result.

Abnormalities can be detected using fMRI scans, such as showing a damaged area in the brain.

Ways of Studying the Brain fMRI brain scan working memory VaiaFig. 3: An fMRI scan shows areas of activity during tasks, such as a memory task.

Electroencephalograms (EEGs)

Electroencephalograms (EEGs) are a type of brain-studying technique where electrodes (up to 34) are placed on the head/scalp with conductive gel. These electrodes detect patterns of activation and electrical activity in the whole brain, made by the many neurones within your brain firing together. These patterns are represented as brain waves:

  • Alpha.

  • Beta.

  • Theta.

  • Delta.

The amplitude is the brain wave's size and intensity, and the frequency is the distance between each wave, showing the speed of activation. We can infer consciousness and brain activity by analysing brain waves.

EEGs are often used in sleep studies, as they can detect the changes in brain waves that indicate different stages of sleep.

If a person is suffering from a sleep disorder, an EEG can help identify where problems are occurring, detecting abnormal brain waves.

They can also be used in other disorders, highlighting their diagnostic properties.

Ways of Studying the Brain EEG data brainwaves VaiaFig. 4: Brainwave EEG data over the course of ten seconds.

Event-Related Potentials (ERPs)

Event-related potentials (ERPs) are very similar to EEGs because they also use electrodes and record the tiny electrical changes in the neurons of the brain. The difference is that researchers present participants with a stimulus many times, and each wave response is added to a pool of data. This creates a smooth activation curve of the collected data, called statistical averaging.

Statistical averaging allows ERPs to remove background noise that has nothing to do with the stimulus, so researchers can say with greater certainty that activation is due to the stimulus and not just background noise. The waves have peaks and troughs that represent cognitive processes in the brain and are called event-related potentials.

ERPs are great for use in memory studies.

Ways of Studying the Brain EEG ERP test VaiaFig. 5: An EEG measures brain activity using electrodes.

Techniques Used to Study the Brain in Relation to Behaviour

All of the techniques we have discussed thus far are techniques we can use to study the brain in relation to behaviour. We can infer function, and therefore behaviour, through analysing the brain structures, activity, and any abnormalities associated with a decline in function with these techniques.

For instance, Broca's and Wernicke's areas associated with language function in the brain were initially identified through post-mortems, as dysfunction in language abilities whilst the patients were alive were associated with lesions in these areas found when they had died.

fMRI scans show us functional areas without being invasive.

We can see how if someone were to flex their fingers, an fMRI will show areas of activity in the brain associated with this movement.

EEGs and ERPs can indicate behavioural responses to exposure to a stimulus, and also indicate how behavioural changes can be detected in those with certain disorders.

EEGs can be used to detect abnormal brain waves in patients with schizophrenia. Arora et al. (2021) investigated auditory hallucinations and changes in frequency bands of resting EEG data in hallucinating patients, non-hallucinating patients, and controls.

To give a few examples of how EEGs revealed information on schizophrenia, they found that:

  • Delta and theta waves were largely unaffected by auditory hallucinations.
  • They differed between schizophrenic patients and controls however, highlighting EEG differences exist.
  • Alpha activity was affected by auditory hallucinations.

Amongst other EEG data results.

Ways of Studying the Brain Evaluation

Each method has its own strengths and weaknesses. To give a brief summary of each concerning their resolution:

  • Post-mortem examinations have a high spatial resolution, but cannot prove that the damaged/examined areas are definitely responsible for specific functions. Unfortunately, they can only be performed after death, and infer function rather than causally relate it to brain area.
  • fMRI usually has a highly detailed spatial resolution but poor temporal resolution. They are quite expensive to run, but are non-invasive.
  • EEGs have a great temporal resolution but poor spatial resolution.
  • ERPs have a high temporal resolution, but like EEGs, poor spatial resolution.
MethodTechnique descriptionAdvantagesDisadvantages
Post-mortem examinationsFixation and examination of dead brain tissues.High spatial resolutionCannot prove the functions of brain regions (inference only)
fMRIDetection of the change in blood flow in the brain using a magnetic field.High spatial resolutionNon-invasivePoor temporal resolutionExpensive
EEGDetection of electric activity in the brain using electrodes placed on the scalp.Good temporal resolutionPoor spatial resolution
ERPDetection of electric activity in the brain using electrodes placed on the scalp on repeated occasions to average the findings.High temporal resolutionPoor spatial resolution
Table 1. Summary table of the ways of studying the brain.

Ways of studying the brain - Key takeaways

  • There are many different ways to study the brain, most notably post-mortem examinations, fMRI, EEG, and ERP.
  • Spatial resolution is the degree of accuracy a technique achieves in examining brain activity. Temporal resolution is the degree of accuracy in determining activity in the brain over time that the technique provides.
  • Post-mortem examinations occur after death and assign a function to damaged areas by analysing the patient's behaviour before death.
  • In fMRIs, magnetic fields are used to detect changes in blood flow in the brain in response to activity, which creates a neuroimage of the brain with the areas highlighted.
  • EEGs and ERPs measure brain waves by attaching electrodes to the scalp to measure activity. EEGs measure activity in the whole brain. In ERPs, the stimulus is given repeatedly to participants.

References

  1. Fig. 2: Post mortem by Internet Archive Book Images, No restrictions, via Wikimedia Commons
  2. Fig. 4: Brain waves by Laurens R. Krol, CC0, via Wikimedia Commons
  3. Fig. 3: fMRI scan by John Graner, Neuroimaging Department, National Intrepid Center of Excellence, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA, Public domain, via Wikimedia Commons
  4. Fig. 5: EEG by Baburov, CC BY-SA 4.0 https://creativecommons.org/licenses/by-sa/4.0, via Wikimedia Commons
  5. Arora M, Knott VJ, Labelle A, Fisher DJ. Alterations of Resting EEG in Hallucinating and Nonhallucinating Schizophrenia Patients. Clinical EEG and Neuroscience. 2021;52(3):159-167. doi:10.1177/1550059420965385

Frequently Asked Questions about Ways of Studying the Brain

There are many different methods to studying the brain. Some common examples are post mortem examinations (an older technique), fMRI scans, EEGs and ERPs, and computerised tomography scans (CT scans) and positron emission tomography scans (PET scans).

We typically study the brain by asking participants to perform a task and then measuring brain activity whilst they complete the task. Alternatively, we may give them a stimulus and measure brain activity during the stimulus. Post-mortems study the brain after death, usually done so if the patient has died due to trauma or damage to the brain.

There are many ways in which scientists study the brain. Post-mortems, fMRI, EEG/ERPs, and computerised tomography scans (CT scans) are a few examples.

These include post-mortem instruments used to extract and examine the brain, functional magnetic resonance imaging machines measure blood flow, and EEGs and ERPs, which use electrodes to measure brain activity.

Final Ways of Studying the Brain Quiz

Ways of Studying the Brain Quiz - Teste dein Wissen

Question

What area of the brain was discovered using post mortems?

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Answer

Broca’s area and the language centres.

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Question

What is spatial resolution? 


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Answer

Spatial resolution is the degree of accuracy that a technique achieves when examining brain activity.

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What is temporal resolution?

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Answer

Temporal resolution is the degree of accuracy in determining brain activity over time that the technique provides.

Show question

Question

What is a post-mortem?

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Answer

It is the examination of the body and brain after death.

Show question

Question

Who typically carries out a post-mortem?

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Answer

A pathologist.

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Question

Why is a chemical fixative used in post-mortems on the brain?

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Answer

The brain is treated using a chemical fixative to make it firm so it can be handled and cut.

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Question

Why are post-mortems correlational and not causal? 


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Answer

They can only suggest a damaged area is responsible for certain brain functions by analysing a patient's behaviour before death and associating that damaged area with the lost/disrupted function.

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Question

How does fMRI measure activity in the brain? 

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Answer

fMRI detects the change of blood flow in the brain using a magnetic field, and this shows increased areas of activity in the brain.

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fMRIs have a good spatial resolution. True or false? 


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Answer

True

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Question

How does EEG measure brain activity?

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Answer

EEG attaches up to 34 electrodes to the scalp, and these electrodes detect activity in the brain.

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What types of brain waves does EEG detect?

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They detect alpha, beta, theta, delta and gamma waves. (Note, gamma waves are not important for the course).

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Does EEG have a good spatial or temporal resolution? 


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Good temporal resolution but poor spatial resolution.

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Question

What do we mean by amplitude and frequency of brain waves in EEGs?

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Answer

Amplitude is the size of the waves, showing the intensity of the brain wave. Frequency is the distance between each wave, showing the speed of the brain activity.

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Question

How does ERP differ from EEG? 

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ERP repeatedly gives the stimulus or activity to the participants to measure the brain activity associated with the stimulus.

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Why is repeated use of a stimulus suitable for measuring brain activity in ERP?

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Answer

It reduces background noise so the brain activity can be ascribed to the stimulus.

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What does EEG stand for?

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Answer

Electroencephalogram.

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How many electrodes are usually used in an EEG or ERP?

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Answer

Around 25, up to 34. This number can increase for more profound readings. 

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How are EEG and ERP results recorded?

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Answer

They are recorded using a graph to show brain waves.

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Question

What are the different names for the brain waves recorded on the graph? 


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Answer

Alpha, beta, theta, delta.

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Define frequency in the context of brain waves.

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Answer

The speed and quantity of the waves.

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Define amplitude in the context of brain waves.

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Answer

The intensity and size of the waves.

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Question

What are synchronised waveforms, and what do they mean?

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Answer

They are waves usually found when the person is asleep or focusing on a task and can be categorised as the alpha, beta, delta, and/or theta waves.

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What are desynchronised waveforms?

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Desynchronized waveforms are more the norm when people are awake, as their brain rapidly switches attention and function. This usually results in a mixture of the above wave types, which is why amplitude and frequency vary so much.

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How do ERPs differ from EEGs?

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ERPs give the stimulus to the participant multiple times, repeating it to average out the results and reduce ‘noise’.

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What is averaging in ERPs? 


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Averaging is where the repeated exposure to a stimulus is measured and graphed over time to provide an average result, eliminating confounding variables.

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What is latency? 


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Latency is the time elapsing between showing the stimulus to the participant and their response to it.

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Question

What happens in the first 100ms after exposure to a stimulus?

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EEGs usually have a short latency in the first 100ms, referred to as sensory ERPs because the senses respond reflexively to the stimulus. After 100ms comes the actual response to the stimulus, where the information has been processed cognitively.

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Question

Name one strength of the EEG and ERP methods. 

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Any of the following: useful for clinical diagnosis, inexpensive, high temporal resolution, non-invasive.

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Name one weakness of the EEG and ERP methods.

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Any of the following: uncomfortable, not exact (superficial), low spatial resolution.

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Why is the ERP more robust than the EEG method?

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ERPs present a stimulus multiple times to a participant and use averaging to filter out unrelated electrical activity, so they can more confidently say that electrical activity directly results from the stimulus. 

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Question

What does fMRI stand for?

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Answer

Functional magnetic resonance imaging.

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What is an fMRI?

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It is a machine for scanning the brain using a magnetic field. It detects blood flow changes occurring due to increased activity within the brain.

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What is hyperactivation?

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It refers to higher levels of activation.

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What carries oxygen to neurones in the brain?

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Haemoglobin.

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What does BOLD stand for?

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Blood oxygenation level-dependent.

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What is a voxel?

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It is a unit of measurement that builds up the 3D image in an fMRI. It represents a small portion of brain tissue.

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Why must a patient be still during fMRI? 


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Answer

To avoid other areas of the brain activating, confounding the results, and to allow for a detailed image to be created. The movement would disrupt this.

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Question

Name one strength of using an fMRI.

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Answer

Any of the following: 

  • It is non-invasive. 
  • It has a high spatial resolution. 
  • It is accurate in building a map of the brain. 
  • It is good at assigning functions to an area of the brain.

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Question

Which of the following is correct?

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Answer

Blood flow is difficult to interpret in an fMRI.

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Name one weakness of using an fMRI.

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Answer

Any of the following: 

  • It is expensive. 
  • It has a low temporal resolution. 
  • The patient has to be still.

Show question

Question

What is a post mortem examination in psychology?

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Answer

It is the examination of the brain after death.

Show question

Question

Who typically carries out a post mortem?

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Answer

A pathologist.

Show question

Question

Why would a coroner request a post mortem?

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Answer

If the death was unusual or suspicious, a coroner may request a post mortem.

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Question

What two areas of the brain were given functional associations after a post mortem? 


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Answer

Broca’s and Wernicke’s areas.

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Question

What chemical fixative can be given during a post mortem to make the brain firm for examination?

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Answer

Formaldehyde.

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Question

What did Mackay et al. find in their study? 


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Answer

In post mortem examinations, the brains of patients with schizophrenia had an increased amount of dopamine and more dopamine receptors compared to a neurotypical person.

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Question

What did Annese et al. find in their study?

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Answer

The patient HM had lesions in his hippocampus, which would help explain why he was unable to store new memories. 

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Question

Name one strength of post mortem examinations.

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Answer

Any of the following: they give a detailed examination of the brain, they can allow deeper inspections of the brain, they are historically relevant as they’ve provided evidence of functional areas in the past (Broca’s and Wernicke’s). 

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Question

Name one weakness of post mortem examinations. 


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Answer

Any of the following: they are ethically questionable with a lack of informed consent, they are not causal, they do not fully take into account other variables, such as age and medications before death affecting the areas being examined. 

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Question

Why was HM’s case ethically questionable?

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Answer

He had amnesia, so was unable to give fully informed consent to the post mortem.

Show question

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